HOW TRELEGY WORKS

Breathing easier, explained

The power of 3 medicines in 1 inhaler

Each of the 3 different long-acting medicines in once-daily TRELEGY has a distinct role. Let’s take a closer look inside the lungs to see how they work together to help make breathing easier and improve lung function for a full 24 hours. In studies, patients taking TRELEGY had improved lung function vs patients taking 2 of TRELEGY's 3 medicines. Your results may vary.

TRELEGY does not replace a rescue inhaler.

PLAY VIDEO | 4:02

View transcript

ANNOUNCER:
This is the story of your lungs and what can make breathing difficult if you live with COPD or asthma. Let’s discover what’s happening in your airways to see why the right treatment may make a difference.

TEXT ONSCREEN:
Graphics and animation for illustrative purposes only.

ANNOUNCER:
When you breathe in, air flows into your nose or mouth, through your throat, and down into your lungs.

Inside your lungs, there’s a system of airways that branch into thousands of smaller airways. Let’s take a closer look inside one of these many airways.

In healthy lungs, air flows in and out of the airways without any issue. But if you’re living with COPD or asthma, breathing can be a lot more difficult. That’s because, over time, your airways can become inflamed from COPD or asthma. This inflammation causes the inner walls of the airways to swell and become thicker.

The muscles around the airways also tighten and constrict, further narrowing them.
All of this makes it difficult for air to flow through when you breathe. This is when you might start to experience breathing problems and uncomfortable symptoms like coughing, wheezing, or being out of breath.

And over time, it can really feel like your symptoms are standing in the way of your everyday life. But if you’ve been feeling this way, you can make a change.

Now is the time to take action and ask your doctor about TRELEGY.

ANNOUNCER AND TEXT ONSCREEN:
Once-daily TRELEGY is a prescription medicine used long term to treat COPD, including chronic bronchitis, emphysema, or both and to treat asthma in adults. TRELEGY 100/62.5/25 mcg is the only strength approved for COPD. TRELEGY is not used to relieve sudden breathing problems and won’t replace a rescue inhaler.

ANNOUNCER:
TRELEGY is taken just once a day.
And it’s the only once-daily treatment...

TEXT ONSCREEN:
ONCE A DAY

ANNOUNCER:
...with 3 medicines in 1 inhaler that lasts for a full 24 hours.

Each of the 3 medicines in TRELEGY has a different role,...

TEXT ONSCREEN:
[ICS medicine disc]
[LABA medicine disc]
[LAMA medicine disc]

ANNOUNCER:
…but they work together to help you breathe easier and improve lung function.

TEXT ONSCREEN:
Results may vary.

ANNOUNCER:
The first medicine is called an ICS, which stands for inhaled corticosteroid. Over time, it reduces inflammation and swelling in the airways to allow more air to flow through.

TEXT ONSCREEN:
[ICS medicine disc]

ANNOUNCER:
The second medicine is called a LABA, or long-acting beta2-adrenergic agonist. It relaxes the muscles around your airways to help open them further.

TEXT ONSCREEN:
[LABA medicine disc]

ANNOUNCER:
And then there’s a third medicine in TRELEGY called a LAMA, or long-acting muscarinic antagonist. This medicine blocks the tightening of muscles around your airways to help keep them open, allowing even more air to flow through.

TEXT ONSCREEN:
[LAMA medicine disc]

ANNOUNCER:
With just one dose, once a day,…

TEXT ONSCREEN:
ONE DOSE
ONCE A DAY

ANNOUNCER:
...you can experience the lasting effects of TRELEGY for a full 24 hours.

TEXT ONSCREEN:
24h

TRELEGY does not replace a rescue inhaler.

ANNOUNCER:
And with the power of 3 medicines together,…

TEXT ONSCREEN:
POWER OF 3

[ICS medicine disc]
[LAMA medicine disc]
[LABA medicine disc]

In studies, patients taking TRELEGY had improved lung function vs patients taking 2 of TRELEGY’s 3 medicines.

ANNOUNCER:
...TRELEGY helps make breathing easier, and improves symptoms all day and night.

TEXT ONSCREEN:
In studies, patients taking TRELEGY had improved lung function vs patients taking 2 of TRELEGY’s 3 medicines.

Results may vary.

ANNOUNCER:
TRELEGY won’t replace a rescue inhaler for sudden breathing problems.

TEXT ONSCREEN:
TRELEGY won’t replace a rescue inhaler.

ANNOUNCER:
TRELEGY contains a medicine that increases risk of hospitalizations and death from asthma problems when used alone for asthma.

When this medicine is used with an inhaled corticosteroid, like in TRELEGY, there is not a significant increased risk of these events.

Tell your doctor if you have a heart condition or high blood pressure before taking it. Do not take TRELEGY more than prescribed.

TEXT ONSCREEN:
Use TRELEGY only once a day, every day.

ANNOUNCER:
Get emergency care for serious allergic reactions. TRELEGY may increase your risk of thrush, infections, and osteoporosis. TRELEGY may also increase your risk of pneumonia if taking it for COPD.

TEXT ONSCREEN:
Serious allergic reactions include rash, hives, mouth and tongue swelling, or breathing problems.

ANNOUNCER:
Call your doctor if your asthma does not improve, or if you experience worsened breathing, chest pain, problems urinating, vision changes, or eye pain.

TEXT ONSCREEN:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

ANNOUNCER:
If you’re living with COPD or asthma, better breathing is within reach.

TEXT ONSCREEN:
ASK YOUR DOCTOR ABOUT ONCE-DAILY TRELEGY

Please see additional Important Safety Information and full Prescribing Information, including Patient Information, on this webpage.

ANNOUNCER:
Make today the day you ask your doctor about once-daily TRELEGY.

TEXT ONSCREEN:
ASK YOUR DOCTOR ABOUT ONCE-DAILY TRELEGY

[GSK logo]

Intended for US audiences only.
The shape of the ELLIPTA inhaler is a trademark of the GSK group of companies. Trademarks are owned by or licensed to the GSK group of companies.

Triple therapy. 24 hours of better breathing.

ICS

(Inhaled corticosteroid) is an anti-inflammatory, meaning it reduces inflammation and swelling in your lungs

LABA

(Long-acting beta₂-adrenergic agonist) is a bronchodilator that opens airways by relaxing the muscles around the airways in your lungs

LAMA

(Long-acting muscarinic antagonist) is another bronchodilator that keeps airways open by blocking the tightening of smooth muscle around your airways

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Approved Uses & Safety Info

Approved Uses

Once-daily TRELEGY is a prescription medicine used long term to treat COPD, including chronic bronchitis, emphysema, or both and to treat asthma in adults. TRELEGY 100/62.5/25 mcg is the only strength approved for COPD. TRELEGY is not used to relieve sudden breathing problems and won’t replace a rescue inhaler.

Limitations of Use
TRELEGY is not used to relieve sudden breathing problems and will not replace a rescue inhaler. TRELEGY should not be used in children younger than 18 years of age. It is not known if TRELEGY is safe and effective in children younger than 18 years of age.

Important Safety Information

TRELEGY contains vilanterol. Long-acting beta₂-adrenergic agonist (LABA) medicines such as vilanterol,

TRELEGY contains vilanterol. Long-acting beta₂-adrenergic agonist (LABA) medicines such as vilanterol, when used alone, increase the risk of hospitalizations and death from asthma problems. TRELEGY contains an ICS, an anticholinergic, and a LABA. When an ICS and LABA are used together, there is not a

TRELEGY contains vilanterol. Long-acting beta₂-adrenergic agonist (LABA) medicines such as vilanterol, when used alone, increase the risk of hospitalizations and death from asthma problems. TRELEGY contains an ICS, an anticholinergic, and a LABA. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems.
Do not use TRELEGY to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
TRELEGY should not be used in children younger than 18 years of age. It is not known if TRELEGY is safe and effective in children.
Do not use TRELEGY if you have a severe allergy to milk proteins or are allergic to any of the ingredients in TRELEGY. Ask your healthcare provider if you are not sure.
Do not use TRELEGY more often than prescribed.
Do not take TRELEGY with other medicines that contain a LABA or an anticholinergic for any reason. Tell your healthcare provider about all your medical conditions and about all the medicines you take.
Call your healthcare provider or get medical care right away if your breathing problems get worse, if you need your rescue inhaler more often than usual or it does not work as well to relieve your symptoms.
TRELEGY can cause serious side effects, including:
- fungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using TRELEGY to help reduce your chance of getting thrush.
- pneumonia. People with COPD have a higher chance of getting pneumonia. TRELEGY may increase the chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms: change in amount or color of mucus; fever; chills; increased cough; increased breathing problems.
- weakened immune system and increased chance of getting infections.
- reduced adrenal function. This can happen when you stop taking oral corticosteroids and start taking inhaled corticosteroids.
- sudden breathing problems immediately after inhaling TRELEGY. If this happens, stop taking TRELEGY and call your healthcare provider right away.
- serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms: rash; hives; swelling of your face, mouth, and tongue; breathing problems.
- effects on heart: increased blood pressure; a fast or irregular heartbeat, awareness of heartbeat; chest pain.
- effects on nervous system: tremor; nervousness.
- bone thinning or weakness (osteoporosis).
- eye problems including glaucoma, increased pressure in your eye, cataracts, blurred vision, worsening of narrow-angle glaucoma, or other changes in vision. You should have regular eye exams while using TRELEGY. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include: eye pain or discomfort; nausea or vomiting; blurred vision; seeing halos or bright colors around lights; red eyes. If you have these symptoms, call your healthcare provider right away before taking another dose.
- new or worse urinary retention. Symptoms may include: difficult, painful, or frequent urination; urination in a weak stream or drips. If you have these symptoms, stop taking TRELEGY and call your healthcare provider right away.
- changes in laboratory blood values, including high levels of blood sugar (hyperglycemia) and low levels of potassium (hypokalemia).
- slowed growth in children.
Common side effects of TRELEGY 100/62.5/25 mcg for COPD include: upper respiratory tract infection; pneumonia; bronchitis; thrush in your mouth and throat (rinse your mouth with water without swallowing after use to help prevent this); headache; back pain; joint pain; flu; inflammation of the sinuses; runny nose and sore throat; taste disturbance; constipation; painful and frequent urination (signs of a urinary tract infection); nausea, vomiting, and diarrhea; mouth and throat pain; cough; and hoarseness.
Common side effects of TRELEGY for asthma include: runny nose and sore throat; upper respiratory tract infection; bronchitis; respiratory tract infection; inflammation of the sinuses; painful and frequent urination (signs of a urinary tract infection); flu; headache; back pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088

GSK For You — If you don’t have prescription coverage, need cost information, or need help paying for your medicine, visit GSKforyou.com or call 1-866-GSK-FOR-U

The shape of the ELLIPTA inhaler is a trademark of the GSK group of companies.

Trademarks are property of their respective owners.

HOW TRELEGY WORKS

Breathing easier, explained

The power of 3 medicines in 1 inhaler

PLAY VIDEO | 4:02

Triple therapy. 24 hours of better breathing.

ICS

LABA

LAMA

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